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Comorbidities: Type 2 diabetes: Both are FDA-approved for diabetes (tirzepatide as Mounjaro, semaglutide as Ozempic) Cardiovascular disease: Semaglutide has the cardiovascular outcomes data Sleep apnea: Tirzepatide has shown benefits Injection frequency: Both are once-weekly

However, ABT-737 shows limited aqueous solubility and oral bioavailability

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Lian, P., et al